How is Chlorthalidone dosed?
For adults with fluid retention (edema), the initial dose of chlorthalidone is typically 50 to 100 milligrams (mg) once a day, or 100 mg once every other day. The dose may be adjusted by your doctor as needed.
For adults with high blood pressure, the initial dose may vary depending on the specific medication prescribed. For Chlorthalidone, the initial dose is 25 mg once a day, and it may be adjusted by your doctor as needed. For Thalitone, the initial dose is 15 mg once a day, and after 2 weeks, the dose may be increased to 25 mg per day as needed.
The use and dose for children must be determined by a doctor.
Consult your doctor for personalized dosage instructions and any concerns about side effects or interactions.
What is the dosage form of Chlorthalidone?
Chlorthalidone is available in oral tablet form.
What medications are contraindication with Chlorthalidone?
Chlorthalidone should be used cautiously with the following medications due to potential interactions or adverse effects:
- Lithium: Concomitant use may increase the risk of lithium toxicity, which can lead to serious side effects such as tremors, seizures, or coma. Close monitoring of lithium levels and kidney function is recommended.
- Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Simultaneous use of chlorthalidone and NSAIDs can increase the risk of renal impairment, including decreased renal blood flow and tubular damage. Monitor for signs of renal dysfunction, such as azotemia or decreased urine output.
- Potassium-sparing diuretics (e.g., amiloride, spironolactone): Concurrent use may result in hyperkalemia (increased potassium levels), which can be dangerous and even life-threatening in some cases. Combining these medications should be avoided, and appropriate monitoring of electrolytes is essential.
- Salicylates (e.g., aspirin): Simultaneous use may decrease the effectiveness of chlorthalidone by inhibiting its metabolism. Monitor blood pressure and adjust the chlorthalidone dose if necessary.
- ACE inhibitors or angiotensin receptor blockers (ARBs): Combining these medications with chlorthalidone can lead to increased risk of hyperkalemia, especially in patients with renal impairment. Close monitoring is necessary, and consideration should be given to using alternative medications or adjusting the dose of chlorthalidone.
Consult your doctor or pharmacist before combining chlorthalidone with any other medications to ensure safe use and minimize potential interactions.
How is Chlorthalidone administered?
Chlorthalidone can be administered orally as tablets. The dosage form depends on the medical issue for which the medicine is being used:
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For fluid retention (edema) in adults: Initially, 50 to 100 milligrams (mg) once a day, or 100 mg once every other day. The dose may be adjusted by your doctor if needed. For children, the use and dose must be determined by a doctor.
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For high blood pressure:
- Chlorthalidone: Initially, 25 milligrams (mg) once a day. Your doctor may adjust your dose if needed.
- Thalitone: Initially, 15 mg once a day. After 2 weeks, your dose may be increased to 25 mg per day as needed. For children, the use and dose must be determined by a doctor.
Consult your doctor for the appropriate dosage and administration instructions.
What are common precautions when taking Chlorthalidone?
Common precautions when taking chlorthalidone orally include monitoring for potential side effects, informing your doctor of any allergies or medical conditions, and adjusting the dose based on age or kidney function. It is crucial to follow your doctor's instructions and not exceed the recommended dosage. Avoid taking chlorthalidone with other diuretics or medications that may increase potassium levels, and inform your doctor of any other medications you are currently taking. Additionally, be cautious in the sun, as chlorthalidone may cause severe sunburn, and consult your doctor before using this medication while breastfeeding.