Estrogen Vaginal Route

How is Estrogen Vaginal Route dosed?

For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (urothritis) in postmenopausal women, the usual dosage of estrogen administered vaginally or topically is:

• Estradiol: One insert containing 2 to 24.8 milligrams (mg) of estradiol inserted into the vagina every three months. The insert will slowly release estradiol at a rate of 7.5 to 100 micrograms (mcg) every twenty-four hours with continuous use.
• Estrone:
  • Vaginal dosage form (cream): Adults can use 2 to 4 milligrams (mg) of estrone (two to four grams of cream) inserted into the vagina once a day or as directed by their doctor.
  • Vaginal dosage form (suppository): Adults can use 2 to 4 milligrams (mg) of estrone (two to four grams of suppository) inserted into the vagina once a day or as directed by their doctor.

Please note that these dosages may vary depending on the individual patient and the specific medical condition being treated. Always follow your doctor's prescription and instructions for proper dosing.

What is the dosage form of Estrogen Vaginal Route?

Estradiol and estrone are the two types of estrogen vaginal route available. They come in different dosage forms, including:

1. For Estradiol:

• Vaginal dosage form (cream): Used for treating genital skin conditions (vulvar atrophy) and inflammation of the vagina (atrophic vaginitis).
• Vaginal dosage form (insert or ring): Used for treating genital skin conditions (vulvar atrophy), inflammation of the vagina (atrophic vaginitis) in postmenopausal women, and inflammation of the urethra (urethritis) in postmenopausal women.

2. For Estrone:

• Vaginal dosage form (cream): Used for treating genital skin conditions (vulvar atrophy) and inflammation of the vagina (atrophic vaginitis) in postmenopausal women.
• Vaginal dosage form (suppository): Used for treating genital skin conditions (vulvar atrophy) and inflammation of the vagina (atrophic vaginitis) in postmenopausal women.

Please consult your doctor for the appropriate dosage, as it may vary based on individual medical conditions and treatments.

What medications are contraindication with Estrogen Vaginal Route?

There are several medications that may interact with estrogen used vaginally. Some of the contraindicated medications include:

1. Antibiotics: Certain antibiotics, such as rifampin, can decrease the effectiveness of vaginal estrogens by decreasing their absorption into the bloodstream.
2. Antifungal medications: Some antifungal medications, like griseofulvin, can interfere with the absorption of vaginal estrogens and may reduce their effectiveness.
3. Anti-seizure medications: Certain anti-seizure medications, such as barbiturates, phenytoin, and carbamazepine, can increase the metabolism of estrogens, reducing their effectiveness.
4. Herbal products: Some herbal products, like St. John's Wort, can interfere with the metabolism of estrogens and may reduce their effectiveness.
5. Aromatase inhibitors: Medications like anastrozole and letrozole, which are used to treat breast cancer, can decrease the amount of estrogen in the body and may interfere with the effectiveness of vaginal estrogens.

It is essential to consult with your healthcare provider. They will be able to provide personalized advice based on your medical history and current medications.

How is Estrogen Vaginal Route administered?

The vaginal route of estrogen administration involves using or applying the hormone directly to the vagina or the surrounding area. This route is used to treat conditions such as vaginal dryness, itching, soreness, or pain during sexual intercourse. Estrogen vaginal preparations are available in various forms, including insert, extended release, capsule, liquid-filled, and cream. It's important to follow your doctor's prescription and instructions for proper use to ensure the desired effects and minimize potential side effects.

What are common precautions when taking Estrogen Vaginal Route?

Here are some common precautions when taking estrogen vaginal route:

1. Follow your doctor's orders or the directions on the label when using estrogen medication.
2. Do not flush vaginal inserts down the toilet; wrap them up and throw them in the trash.
3. Dosage depends on the strength of the medicine, the medical problem for which it is being used, and the number of doses taken each day.
4. Estrogens used vaginally at very low doses may not protect against osteoporosis or stop hot flashes caused by menopause.
5. If you have problems removing the vaginal insert, contact your doctor.
6. It is not necessary to remove the vaginal insert for sexual intercourse, but if you do remove it or if it accidentally slips out, you can replace it after washing it with lukewarm water.
7. Replace the vaginal insert every 3 months, and talk to your doctor on a regular basis about how long to use it.
8. Regularly discuss the use of vaginal estrogens with your doctor, especially if you have any special risks or concerns.

Remember that this information is based on an average dosage and may not apply to everyone. Consult your doctor for personalized advice and guidance on the use of estrogen vaginal route.