Lumacaftor and Ivacaftor Oral Route

How is Lumacaftor and Ivacaftor Oral Route dosed?

The dosage of lumacaftor and ivacaftor oral route varies based on age, weight, and the medical condition being treated. For cystic fibrosis patients, the recommended dosages are as follows:

• Adults and children 12 years and older: Take 2 tablets every 12 hours with fat-containing food. Each tablet contains 200mg lumacaftor and 125mg ivacaftor.

• Children 6 to 11 years of age: Take 2 tablets every 12 hours with fat-containing food. Each tablet contains 100mg lumacaftor and 125mg ivacaftor.

• Children 2 to 5 years of age: The dosage is determined by a doctor based on body weight.

• Children weighing 14kg or more: Take 1 packet of granules every 12 hours with fat-containing food. Each packet contains 150mg lumacaftor and 188mg ivacaftor.

• Children weighing less than 14kg: Take 1 packet of granules every 12 hours with fat-containing food. Each packet contains 100mg lumacaftor and 125mg ivacaftor.

For children under 1 year of age, the dosage should be determined by a doctor.

What is the dosage form of Lumacaftor and Ivacaftor Oral Route?

Lumacaftor and ivacaftor oral route is available in the following dosage forms:

1. Granules
2. Tablets

How is Lumacaftor and Ivacaftor Oral Route administered?

Lumacaftor and ivacaftor oral route is administered in the form of tablets or granules, depending on the age and weight of the patient. The recommended dosages for cystic fibrosis patients are as follows:

• Adults and children 12 years of age and older weighing 14 kg or more: Take 2 tablets every 12 hours with fat-containing food. Each tablet contains 200 mg lumacaftor and 125 mg ivacaftor.

• Children 6 to 11 years of age weighing 14 kg or more: Take 2 tablets every 12 hours with fat-containing food. Each tablet contains 100 mg lumacaftor and 125 mg ivacaftor.

• Children 2 to 5 years of age: The dosage is determined by a doctor based on body weight.

• Children 1 to 2 years of age weighing less than 14 kg: Take 1 packet of granules every 12 hours with fat-containing food. Each packet contains 100 mg lumacaftor and 125 mg ivacaftor.

• Children younger than 1 year of age: Use and dose must be determined by a doctor.

For oral dosage form (granules):

• Patients weighing 14 kg or more: Take 1 packet of granules every 12 hours with fat-containing food. Each packet contains 150 mg lumacaftor and 188 mg ivacaftor.

• Patients weighing less than 14 kg: Take 1 packet of granules every 12 hours with fat-containing food. Each packet contains 100 mg lumacaftor and 125 mg ivacaftor.

It is essential to follow the doctor's instructions and the medication guide for the correct administration and dosage. Always consult with a healthcare professional before starting any medication.

What are common precautions when taking Lumacaftor and Ivacaftor Oral Route?

Common precautions when taking lumacaftor and ivacaftor oral route include:

1. Informing your doctor about any allergies: Let your doctor know if you have had any unusual or allergic reactions to this medicine or any other medicines. Also, mention any other types of allergies, such as to foods, dyes, preservatives, or animals.

2. Consulting a healthcare professional: Inform your healthcare professional if you have any other medical conditions, especially liver or kidney problems, diabetes, or high blood pressure.

3. Using with caution in specific populations: Lumacaftor and ivacaftor combination has not been studied in pediatric patients under 1 year of age and in geriatric patients. Safety and efficacy have not been established in these age groups.

4. Monitoring during breastfeeding: There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

5. Drug interactions: Be cautious about potential interactions with other medications. Inform your doctor about all the medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

6. Following dosage instructions: Take the medicine exactly as prescribed by your doctor. The dose, number of doses per day, time between doses, and length of treatment depend on the medical problem for which you are using the medicine.

Always consult with your doctor or pharmacist for specific precautions and instructions when taking lumacaftor and ivacaftor oral route.