Osimertinib

How is Osimertinib dosed?

Dosage forms of osimertinib include tablets.

What medications are contraindication with Osimertinib?

Osimertinib is contraindicated with the following medications:

1. Bepridil
2. Cisapride
3. Dronedarone
4. Levoketoconazole
5. Mesoridazine
6. Pimozide
7. Piperaquine
8. Saquinavir
9. Sparfloxacin
10. Terfenadine
11. Thioridazine
12. Ziprasidone Please consult your doctor for further information and advice on potential drug interactions or contraindications specific to your medical history and current medications.

How is Osimertinib administered?

Osimertinib is taken orally with or without food. If you have difficulty swallowing the tablet, you can dissolve it in 2 ounces (60 milliliters) of non-carbonated water. Do not crush or heat the tablet. After stirring until the tablet is in small pieces, drink the liquid right away. Then, add an additional 4 to 8 ounces (120 to 240 mL) of water to the container and consume immediately. In some cases, the medicine can also be given through a nasogastric tube by dissolving the tablet in 15 mL of non-carbonated water, followed by an additional 15 mL of water to transfer the medicine to the syringe.

What are common precautions when taking Osimertinib?

Common precautions when taking osimertinib include:

1. Allergies: Inform your doctor about any allergic reactions or allergies to medications, foods, dyes, preservatives, or animals.
2. Pediatric Use: Osimertinib's safety and efficacy have not been established in the pediatric population. Consult your doctor for appropriate guidance.
3. Geriatric Use: Use with caution in elderly patients as they may be more susceptible to serious side effects. Close monitoring is advised.
4. Drug Interactions: Inform your doctor about all medications, supplements, or herbal products you are taking, as interactions may occur.
5. Electrolyte or Mineral Imbalance: Osimertinib may worsen conditions related to electrolyte or mineral imbalances. Inform your doctor if you have a history of such conditions.
6. Heart Disease or Rhythm Problems: Use with caution if you have heart disease or heart rhythm problems, as osimertinib may exacerbate these conditions.
7. Lung Disease or Breathing Problems: Consult your doctor if you have a history of lung disease or breathing problems, as osimertinib may worsen these conditions.
8. Keratitis: Inform your doctor if you have a history of keratitis (inflammation of the cornea of the eye), as osimertinib may worsen this condition.
9. Proper Use: Follow your doctor's instructions regarding dosage and frequency. Do not exceed the prescribed dose or duration.
10. Patient Information Insert: Read and carefully follow the instructions provided with the medication. Consult your doctor if you have any questions. Always consult your healthcare professional for personalized advice regarding precautions and potential side effects.