How is Progestin dosed?
Progestins can be dosed in various ways, depending on the specific form and intended use. For oral progestins, the typical dosages are as follows:
- For preventing endometrial hyperplasia when taking estrogen for ovarian hormone therapy in postmenopausal women: 200 mg per day at bedtime for 12 continuous days per 28-day cycle of estrogen treatment each month.
- For treating amenorrhea: 400 mg per day at bedtime for ten days.
For vaginal progestins, the dosages are:
- For treating amenorrhea: 45 mg (one applicatorful of 4% gel) once every other day for up to six doses. Dose may be increased to 90 mg (one applicatorful of 8% gel) once every other day for up to six doses if needed.
- For use with infertility procedures: 90 mg (one applicatorful of 8% gel) one or two times a day. If pregnancy occurs, treatment can continue for up to ten to twelve weeks.
For parenteral progestins (e.g., injections), the dosages are typically based on the individual's age, medical condition, and the specific progestin used. It is crucial to follow your doctor's instructions and dosage recommendations as they may vary based on individual factors.
What is the dosage form of Progestin?
Progestin is available in several dosage forms, including oral, parenteral (injection), and vaginal routes. Here are the details of each dosage form:
- Oral dosage form (capsules):
- For preventing endometrial hyperplasia in postmenopausal women taking estrogen for ovarian hormone therapy: 200 milligrams (mg) per day at bedtime for 12 continuous days per 28-day cycle of estrogen treatment each month.
- For treating amenorrhea (absence of menstrual periods): 400 mg per day at bedtime for ten days.
- Vaginal dosage form (gel):
- For treating amenorrhea: 45 mg (one applicatorful of 4% gel) once every other day for up to six doses. The dose may be increased to 90 mg (one applicatorful of 8% gel) once every other day for up to six doses if needed.
- For use with infertility procedures: 90 mg (one applicatorful of 8% gel) one or two times a day. If pregnancy occurs, treatment can continue for up to ten to twelve weeks.
- Injection dosage form:
- For controlling abnormal and heavy vaginal bleeding (dysfunctional uterine bleeding) or treating amenorrhea: 5 to 10 mg a day injected into a muscle for six to ten days. Alternatively, your doctor may prescribe 100 or 150 mg as a single dose. In some cases, your doctor may advise you to first take another hormone called estrogen. When your menstrual period begins, your doctor will recommend stopping the medication.
- Vaginal dosage form (suppositories):
- For maintaining a pregnancy (at ovulation and early pregnancy): 25 mg to 100 mg (one suppository) inserted into the vagina one or two times a day, starting near the time of ovulation. Your doctor may recommend
How is Progestin administered?
Progestin can be administered orally, parenterally (through injection or implant), vaginally (as suppositories), and rectally (as suppositories). The specific route of administration depends on the individual patient's needs and the medical professional's prescription. Oral progestins can be in the form of tablets, capsules, or suspensions. Vaginal progestins are available as suppositories, while rectal progestins are available as suppositories as well. It is crucial to follow the doctor's instructions and take the medication as directed to ensure its effectiveness and minimize potential side effects.