How is Regorafenib dosed?
For hepatocellular cancer (HCC):
- Adults: The recommended dose is 160 milligrams (mg) (four 40 mg tablets) once a day for 21 days of each 28-day cycle. The dose may be adjusted if necessary.
- Children: The dose must be determined by a doctor.
For metastatic cancer of the colon or rectum:
- Adults: The recommended dose is 160 milligrams (mg) (four 40 mg tablets) once a day for 21 days of each 28-day cycle. The dose may be adjusted if necessary.
- Children: The dose must be determined by a doctor.
For metastatic gastrointestinal stromal tumors (GIST):
- Adults: The recommended dose is 160 milligrams (mg) (four 40 mg tablets) once a day for 21 days of each 28-day cycle. The dose may be adjusted if necessary.
- Children: The dose must be determined by a doctor.
What is the dosage form of Regorafenib?
Regorafenib is available in tablet form.
How is Regorafenib administered?
Regorafenib tablets should be swallowed whole with water. They should not be crushed, broken, or chewed. The tablets should be taken at the same time each day with a low-fat meal (less than 30% fat).
What are common precautions when taking Regorafenib?
Common precautions when taking regorafenib include:
- Infection: The medicine may decrease the body's ability to fight infection, so it is important to avoid infections while taking regorafenib.
- Liver disease: Use with caution if you have liver disease, as the effects may be increased due to slower removal of the medicine from the body.
- Proper use: Follow your doctor's instructions and take the medicine as directed.
- Drug interactions: Inform your doctor about any other medications you are taking, as some may interact with regorafenib and affect its efficacy or cause adverse reactions.
- Allergies: Discuss any allergies you have with your healthcare professional.
- Pediatric and Geriatric use: Safety and efficacy of regorafenib have not been established in the pediatric population. There are no geriatric-specific problems known that would limit the usefulness of this medicine in the elderly.
- Side effects: Common side effects include bad taste, hair loss, lack of strength, muscle or joint stiffness, weight loss, constipation, depressed mood, dry skin and hair, feeling cold, and muscle cramps. Inform your doctor if you experience any unusual or severe side effects.