How is Simvastatin and Niacin Oral Route dosed?
The oral dosage form of simvastatin and niacin is typically dosed as follows:
For patients not on niacin or simvastatin therapy:
- Adults: One tablet once a day in the evening. The dose may be adjusted by the doctor if needed, but it is usually not more than 2000 milligrams (mg) of niacin and 40 mg of simvastatin.
- Children: Use and dose are determined by the doctor.
For patients on niacin therapy:
- Adults: One tablet containing 500 milligrams (mg) of niacin and 20 mg of simvastatin once a day in the evening. The dose may be adjusted by the doctor if needed, but it is usually not more than 2000 mg of niacin and 40 mg of simvastatin.
- Children: Use and dose are determined by the doctor.
For patients on simvastatin therapy:
- Adults: One tablet containing 500 mg of niacin and 40 mg of simvastatin once a day in the evening. The dose may be adjusted by the doctor if needed, but it is usually not more than 2000 mg of niacin and 40 mg of simvastatin.
It is important to follow the doctor's instructions regarding dosage and to not change the dose without consulting the doctor first.
What is the dosage form of Simvastatin and Niacin Oral Route?
The oral dosage form for simvastatin and niacin is available in extended-release tablets. The adult dose for patients not on niacin or simvastatin therapy is one tablet once a day in the evening, with the doctor adjusting the dose if needed. For patients on niacin therapy, the adult dose is one tablet containing 500 mg of niacin and 20 mg of simvastatin once a day in the evening. For patients on simvastatin therapy, the adult dose is one tablet containing 500 mg of niacin and 40 mg of simvastatin once a day in the evening. Dosing for children is determined by the doctor. Consult with your healthcare provider for any medication-related questions or concerns.
What medications are contraindication with Simvastatin and Niacin Oral Route?
Simvastatin and niacin oral route is contraindicated with the following medicines: boceprevir, cyclosporine, danazol, gemfibrozil, nefazodone, telaprevir, clarithromycin, erythromycin, itraconazole, ketoconazole, posaconazole, telithromycin, diltiazem, verapamil, atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, or certain HIV/AIDS medications. Taking these medicines together can cause serious side effects.
How is Simvastatin and Niacin Oral Route administered?
For oral dosage form (extended-release tablets):
For high cholesterol:
- For patients not on niacin or simvastatin therapy: Adults - One tablet once a day in the evening. Your doctor may adjust your dose if needed. However, the dose is usually not more than 2000 milligrams (mg) of niacin and 40 mg of simvastatin. Children - Use and dose must be determined by your doctor.
- For patients on niacin therapy: Adults - One tablet (500 milligrams [mg] of niacin and 20 mg of simvastatin) once a day in the evening. Your doctor may adjust your dose if needed. However, the dose is usually not more than 2000 mg of niacin and 40 mg of simvastatin. Children - Use and dose must be determined by your doctor.
- For patients on simvastatin therapy: Adults - One tablet (500 mg of niacin and 40 mg of simvastatin) once a day in the evening. Your doctor may adjust your dose if needed. However, the dose is usually not more than 2000 mg of niacin and 40 mg of simvastatin.
It is best to take this medicine at bedtime, with a low-fat meal or snack. Do not change your dose without checking first with your doctor.
What are common precautions when taking Simvastatin and Niacin Oral Route?
Common precautions when taking simvastatin and niacin oral route include:
- Avoiding certain medications: Do not use simvastatin and niacin together with specific medications such as boceprevir, cyclosporine, danazol, gemfibrozil, nefazodone, telaprevir, clarithromycin, erythromycin, itraconazole, ketoconazole, posaconazole, telithromycin, diltiazem, verapamil, atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, or certain HIV/AIDS medications. These combinations can cause serious side effects.
- Monitoring for muscle problems: Elderly patients are more likely to experience muscle problems when taking this medicine. Your doctor may closely monitor you for muscle-related issues.
- Following a low-fat diet: Your doctor might recommend a low-fat, low-sugar, and low-cholesterol diet to help manage your cholesterol levels. Ensure you follow any dietary instructions provided by your healthcare professional.
- Taking the medication whole and at bedtime: Swallow the extended-release tablet whole and avoid breaking, crushing, or chewing it. It is generally recommended to take the medicine at bedtime with a low-fat meal or snack.
- Consulting your doctor before changing the dose: Do not adjust your dose without consulting your doctor, especially for the 80 mg dose of simvastatin, as it can increase the risk of serious muscle problems.
- Considerations for breastfeeding mothers: There is evidence of harmful effects on infants when breastfeeding while taking this medication. Consult your doctor for an alternative medication or discontinue breastfeeding while using this medicine.
Please consult your healthcare provider for personalized advice and any concerns you may have regarding the use of simvastatin and niacin oral route.