How is Tezacaftor Ivacaftor and Ivacaftor Oral Route dosed?
For cystic fibrosis:
- Adults and children 12 years of age and older: One yellow tablet (tezacaftor 100 mg/ivacaftor 150 mg) taken in the morning and 1 light blue tablet (ivacaftor 150 mg) taken in the evening, about 12 hours apart.
- Children 6 to 11 years of age weighing 30 kilograms (kg) or more: One yellow tablet (tezacaftor 100 mg/ivacaftor 150 mg) taken in the morning and 1 light blue tablet (ivacaftor 150 mg) taken in the evening, about 12 hours apart.
- Children 6 to 11 years of age weighing less than 30 kg: One white tablet (tezacaftor 50 mg/ivacaftor 75 mg) taken in the morning and 1 light blue tablet (ivacaftor 75 mg) taken in the evening, about 12 hours apart.
- Children younger than 6 years of age: Use and dose must be determined by your doctor.
What is the dosage form of Tezacaftor Ivacaftor and Ivacaftor Oral Route?
The oral route dosage forms for tezacaftor/ivacaftor and ivacaftor are tablets. The available dosage strengths are:
- For patients 6 years of age and older, two copies of the F508del mutation, or at least one CFTR gene mutation: One yellow tablet containing 100mg of tezacaftor and 150mg of ivacaftor in the morning, followed by one light blue tablet containing 150mg of ivacaftor in the evening, approximately 12 hours apart.
- For children 6 to 11 years of age weighing 30 kilograms (kg) or more: One yellow tablet containing 100mg of tezacaftor and 150mg of ivacaftor in the morning and one light blue tablet containing 150mg of ivacaftor in the evening, approximately 12 hours apart.
- For children 6 to 11 years of age weighing less than 30 kg: One white tablet containing 50mg of tezacaftor and 75mg of ivacaftor in the morning, followed by one light blue tablet containing 75mg of ivacaftor in the evening, approximately 12 hours apart.
What medications are contraindication with Tezacaftor Ivacaftor and Ivacaftor Oral Route?
The following medications are contraindicated with Tezacaftor/Ivacaftor and Ivacaftor oral route:
- Abametapir
- Adagrasib
- Alfentanil
- Alprazolam
- Amiodarone
- Amprenavir
- Apalutamide
- Aprepitant
- Atazanavir
- Belzutifan
- Bentazepam
- Benzhydrocodone
- Boceprevir
- Bromazepam
- Buprenorphine
- Carbamazepine
- Ceritinib
- Chlordiazepoxide
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clobazam
- Clofazimine
- Clonazepam
- Clorazepate
- Cloxazolam
- Clozapine
- Cobicistat
- Codeine
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Darunavir
- Delorazepam
- Diazepam
- Digoxin
- Dihydrocodeine
- Dihydroergotamine
- Diltiazem
- Dofetilide
- Dronedarone
- Duvelisib
- Eliglustat
- Enzalutamide
- Ergotamine
- Erythromycin
- Estazolam
- Everolimus
- Fedratinib
- Fentanyl
- Fexinidazole
- Finerenone
- Flibanserin
- Fluconazole
- Flunitrazepam
How is Tezacaftor Ivacaftor and Ivacaftor Oral Route administered?
This medication is administered orally in the form of tablets. It is used to treat cystic fibrosis (CF) in patients 6 years of age and older who have two copies of the F508del mutation or at least one mutation in their CFTR gene. The dosage and frequency of administration depend on the patient's age, weight, and specific condition. It is important to follow your doctor's prescription and instructions carefully when taking this medication.
What are common precautions when taking Tezacaftor Ivacaftor and Ivacaftor Oral Route?
Common precautions when taking Tezacaftor/Ivacaftor and Ivacaftor oral route include:
- Allergies: Inform your doctor if you have had any unusual or allergic reactions to this medicine or any other medicines. Also, inform your healthcare professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.
- Pediatric Use: Appropriate studies have not been performed on the relationship of age to the effects of Tezacaftor/Ivacaftor and Ivacaftor combination in children younger than 6 years of age. Safety and efficacy have not been established.
- Geriatric Use: Appropriate studies on the relationship of age to the effects of Tezacaftor/Ivacaftor and Ivacaftor combination have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.
- Breastfeeding: The safety and efficacy of Tezacaftor/Ivacaftor and Ivacaftor combination have not been established in breastfeeding. Consult your doctor before breastfeeding while taking this medication.