How is Tisagenlecleucel dosed?
The recommended dosage of Tisagenlecleucel is based on the patient's weight. For B-cell acute lymphoblastic leukemia (ALL) and follicular lymphoma (FL), the dosage is 2 x 10^6 CAR-positive viable T cells per kilogram of body weight. For example, if a patient weighs 50 kg, the dose would be 1 x 10^6 CAR-positive viable T cells per dose, for a total of 2 x 10^6 CAR-positive viable T cells per dose. Please consult your doctor for personalized dosage instructions.
What is the dosage form of Tisagenlecleucel?
Tisagenlecleucel is available in the form of a suspension.
What medications are contraindication with Tisagenlecleucel?
Tisagenlecleucel may have potential drug interactions. It is important to inform your healthcare professional about any other prescription or nonprescription medications you are taking. Please consult your healthcare professional for guidance on potential drug interactions based on your specific medical history and current medications.
How is Tisagenlecleucel administered?
Tisagenlecleucel is administered intravenously (IV) through a needle placed in a vein, typically in the arm or hand. The administration of the medicine is done under the supervision of a healthcare professional who will follow the restricted distribution program guidelines and provide appropriate monitoring.
What are common precautions when taking Tisagenlecleucel?
Common precautions when taking Tisagenlecleucel include:
- Age considerations: Safety and efficacy of Tisagenlecleucel in the elderly have not been established.
- Breastfeeding: The effects of Tisagenlecleucel on breastfeeding infants are unknown. Consult your doctor before taking this medication while breastfeeding.
- Drug interactions: Inform your healthcare professional about any other prescription or nonprescription medications you are taking.
- Immunizations: Avoid having any immunizations (vaccinations) without your doctor's approval while being treated with Tisagenlecleucel. Live virus vaccinations should not be given for at least 6 weeks before start of treatment, during treatment, and until recovery following the last cycle of this medicine.
- Medical tests: Inform the medical doctor in charge that you are taking Tisagenlecleucel before having any medical tests.
- Side effects: Be aware of common side effects like muscle pain or stiffness, pain in the arms or legs, and stuffy nose. Notify your healthcare professional if you experience any other side effects.
- Driving and operating machinery: Tisagenlecleucel may cause dizziness, confusion, seizures, or decreased alertness. Do not drive or operate machinery until you know how this medicine affects you for at least 8 weeks after treatment.
- Restricted distribution program: Tisagenlecleucel is available only under a restricted distribution program called Kymriah REMS (Risk Evaluation and Mitigation Strategy) Program. Please consult with your doctor for specific guidance based on your medical history and condition.